MI-210: Essentials of Population PKPD M&S

Pumas Edition

1 Overview

Course materials for MI-210 adapted to the Pumas ecosystem. Select a chapter from the sidebar or navbar to get started.

2 Chapters

Chapter	Topic
1	Introduction to Nonlinear Regression and NLME Models
2	Population PK-PD Data Requirements and Formatting
3	Coding Population Nonlinear Mixed Effects Models
4	Covariate Model Building
5	Simulation
6	Model Qualification
7	Direct and Indirect Continuous Pop PK-PD Models

3 Lecture Notes

Lecture notes from the PK and PKPD modeling courses provide the theoretical foundations behind the chapters above. Browse the full collection from the Lectures index, or use the links below.

3.1 Pharmacokinetics (PK) Course

Week	Lecture
1	Foundations of PK Terminology and Data
1	Units, Dimensionality, and Rate Processes
1	Mathematical Foundations of PK
2	One-Compartment IV Bolus Model
3	Drug Transport, Diffusion, and Distribution
4	Volume of Distribution and Protein Binding
5	Volume of Distribution — Mechanisms and Determinants
6	Clearance, Hepatic Extraction, and Intrinsic Clearance
7	Hepatic Clearance — Intrinsic Clearance and Extraction Ratio
7	Well-Stirred Model and Renal Elimination
8	Extravascular Dosing and Oral Absorption
9	IV Infusion Kinetics

3.2 PKPD Modeling Course

Week	Lecture
1	Philosophy, Principles, and Practice
2	Structural Models and Parameter Estimation
4	Population PK Model Components and NLME
5	Base Model Diagnostics and Likelihood Comparison
6	Graphical Diagnostics and Residual Analysis
7	Residual Diagnostics and Error Model Specification
7.5	Covariate Modeling Fundamentals
8	Covariate Diagnostics and Methodology